Tae-Hee Kim
Soonchunhyang University Bucheon Hospital, South KoreaPresentation Title:
Intravenous administration of autologous blood concentrate containing hematopoietic stem cells enhances NK cell activity in female patients: A retrospective observational study
Abstract
Background: Intravenous therapy using autologous blood concentrate containing hematopoietic stem cells has shown potential in the fields of regeneration and immune modulation. This study focuses on treatment response specifically in female patients receiving therapy for various aging-related and chronic conditions.
Objective: To evaluate the effect of intravenous autologous blood concentrate therapy on NK cell activity and immune responose trend in female patients by age group as well as changes in general blood biomarkers.
Methods: 44 female patients (mean age: 56 ± 13 years) were included in this analysis. The primary indications for treatment included anti-aging (n=19, 44.4%), chronic fatigue (n=9, 20.8%), dermatologic conditions (n=6, 12.5%), joint pain (n=3, 6.9%), cancer history (n=3, 5.5%), menopausal symptoms (n=2, 4.1%), diabetes (n=2, 4.1%), and cardiovascular disease (n=1, 1.3%). The treatment formulation was prepared using the Miracell Smart M Cell System and a BSC kit, which concentrate nucleated cells and platelets from whole blood through proprietary centrifugation and separation techniques. The resulting product was administered intravenously. NK cell activity and other biomarkers were measured before and after treatment using IFN-γ release assays.
Results: NK cell activity increased from a baseline average of 504.9 pg/mL to 783.9 pg/mL after treatment, demonstrating a statistically significant enhancement (P < 0.01). Notably, in the subgroup of patients with baseline NK activity below 100 pg/mL (mean: 56.9 pg/mL), post- treatment NK cell activity rose to an average of 609.3 pg/mL, representing an approximate 10.7-fold increase (P < 0.05). NK activity generally improved across all age groups. Conclusion: Intravenous administration of autologous blood concentrate containing hematopoietic stem cells appears to significantly enhance NK cell-mediated immune activity in female patients, particularly those with low baseline NK levels.
Biography
Tae Hee Kim has completed PHD at the age of 39 years from Chung-Ang University in South Korea. She is a professor in the Department of Obstetrics and Gynecology at Soonchunhyang University Bucheon Hospital in Bucheon, Korea. She also serves as the Chair of the Department of Biomedical Science at the Graduate School of Soonchunhyang University in Asan. Previously, she held the position of Chief of the Department of Obstetrics and Gynecology at Soonchunhyang University Bucheon Hospital. She has over 300 publications and her publication h-index is 29. She has been serving as an editorial board member of several reputed journal. She is a fellow of the National Academy of Medicine of Korea (NAMOK).
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